How does the polymer architecture and position of cationic charges affect cell viability?
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Published version
Author(s)
Type
Journal Article
Abstract
Polymer chemistry, composition and molar mass are factors that are known to affect cytotoxicity however the influence of polymer architecture has not been investigated systematically. In this study the influence of the position of the cationic charges along the polymer chain on cytotoxicity was investigated while keeping constant the other polymer characteristics. Specifically, copolymers of various architectures, based on a cationic pH responsive monomer, 2-(dimethylamino)ethyl methacrylate (DMAEMA) and a non-ionic hydrophilic monomer, oligo(ethylene glycol)methyl ether methacrylate (OEGMA) were engineered and their toxicity towards a panel of cell lines investigated. Of the seven different polymer architectures examined, the block-like structures were less cytotoxic than statistical or gradient/tapered architectures. These findings will assist in developing future vectors for nucleic acid delivery.
Date Issued
2023-01-21
Date Acceptance
2022-12-06
Citation
Polymer Chemistry, 2023, 14 (3), pp.303-317
ISSN
1759-9954
Publisher
Royal Society of Chemistry (RSC)
Start Page
303
End Page
317
Journal / Book Title
Polymer Chemistry
Volume
14
Issue
3
Copyright Statement
© The Royal Society of Chemistry 2023. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.
Identifier
https://pubs.rsc.org/en/Content/ArticleLanding/2022/PY/D2PY01012G
Publication Status
Published
Date Publish Online
2022-12-07