A caged E3 ligase ligand for PROTAC-mediated protein degradation with light
File(s)Kounde et al Chem Comm_v2_revised 210320_final.docx (4.75 MB) Supp info_ Kounde et al. Caged PROTAC_Chem Comm_v2 revised(1).docx (6.73 MB)
Accepted version
Supporting information
Author(s)
Type
Journal Article
Abstract
With the intent of achieving greater spatiotemporal control of PROTAC-induced protein degradation, a light-activated degrader was designed by photocaging an essential E3 ligase binding motif in a BRD4 targeting PROTAC. Proteolysis was triggered only after a short irradiation time, the kinetics of which could be monitored by live-cell video microscopy.
Date Issued
2020-05-21
Date Acceptance
2020-03-31
Citation
Chemical Communications, 2020, 56 (41), pp.5532-5535
ISSN
1359-7345
Publisher
Royal Society of Chemistry
Start Page
5532
End Page
5535
Journal / Book Title
Chemical Communications
Volume
56
Issue
41
Copyright Statement
© The Royal Society of Chemistry 2020.
Sponsor
Biotechnology and Biological Sciences Research Council (BBSRC)
Biotechnology and Biological Sciences Research Council (BBSRC)
Grant Number
BB/N016947/1
BB/S001565/1
Subjects
Organic Chemistry
03 Chemical Sciences
Publication Status
Published
Date Publish Online
2020-04-03