Brain imaging and impulse control disorders in Parkinson’s disease
File(s)Roussakis2019_Article_BrainImagingAndImpulseControlD.pdf (243.45 KB)
Published version
Author(s)
Roussakis, Andreas
Lao-Kaim, Nicholas
Piccini, P
Type
Journal Article
Abstract
Purpose of review
Parkinson’s disease (PD) has a wide spectrum of symptoms including the presence of psychiatric disease. At present, most treatment plans, comprised of dopaminergic drugs, are chronic and complex. Though dopaminergic agents are quite efficient in managing the motor aspects of the disease, chronic pharmacotherapy specifically with dopamine receptor agonists has been highly linked to the occurrence of Impulse Compulsive disorder (ICD), which can be problematic for individual patients.
Recent findings
Much of what is known today about PD-related ICD stems from brain imaging studies, however, evidence is not quite conclusive. Research in the field has been focused on identifying the underlying mechanisms of PD-related ICD and understanding the functions of the structures involved in the reward network.
Summary
This article presents an update of recent findings from key neuroimaging studies in PD-related ICD, discusses results from controversial studies, and identifies areas for future research in the field.
Parkinson’s disease (PD) has a wide spectrum of symptoms including the presence of psychiatric disease. At present, most treatment plans, comprised of dopaminergic drugs, are chronic and complex. Though dopaminergic agents are quite efficient in managing the motor aspects of the disease, chronic pharmacotherapy specifically with dopamine receptor agonists has been highly linked to the occurrence of Impulse Compulsive disorder (ICD), which can be problematic for individual patients.
Recent findings
Much of what is known today about PD-related ICD stems from brain imaging studies, however, evidence is not quite conclusive. Research in the field has been focused on identifying the underlying mechanisms of PD-related ICD and understanding the functions of the structures involved in the reward network.
Summary
This article presents an update of recent findings from key neuroimaging studies in PD-related ICD, discusses results from controversial studies, and identifies areas for future research in the field.
Date Issued
2019-09
Date Acceptance
2019-06-05
Citation
Current Neurology and Neuroscience Reports, 2019, 19 (9)
ISSN
1528-4042
Publisher
Springer (part of Springer Nature)
Journal / Book Title
Current Neurology and Neuroscience Reports
Volume
19
Issue
9
Copyright Statement
© The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
License URL
Subjects
Science & Technology
Life Sciences & Biomedicine
Clinical Neurology
Neurosciences
Neurosciences & Neurology
Parkinson's disease
Impulse control disorders
Neuroimaging
PET
SPECT
MRI
STRIATAL DOPAMINE RELEASE
COMPULSIVE DISORDERS
NUCLEUS-ACCUMBENS
CONNECTIVITY
REWARD
PREVALENCE
BEHAVIORS
QUESTIONNAIRE
METAANALYSIS
DEPRESSION
Impulse control disorders
MRI
Neuroimaging
PET
Parkinson’s disease
SPECT
Neurology & Neurosurgery
Publication Status
Published
Article Number
ARTN 67
Date Publish Online
2019-08-08