Dichotomy between T Cell and B Cell Tolerance to Neonatal Retroviral Infection Permits T Cell Therapy
Author(s)
Type
Journal Article
Abstract
Elucidation of the immune requirements for control or elimination of retroviral infection remains an important aim. We studied the induction of adaptive immunity to neonatal infection with a murine retrovirus, under conditions leading to immunological tolerance. We found that the absence of either maternal or offspring adaptive immunity permitted efficient vertical transmission of the retrovirus. Maternal immunodeficiency allowed the retrovirus to induce central Th cell tolerance in the infected offspring. In turn, this compromised the offspring’s ability to mount a protective Th cell–dependent B cell response. However, in contrast to T cells, offspring B cells were not centrally tolerized and retained their ability to respond to the infection when provided with T cell help. Thus, escape of retrovirus-specific B cells from deletional tolerance offers the opportunity to induce protective retroviral immunity by restoration of retrovirus-specific T cell help, suggesting similar T cell immunotherapies for persistent viral infections.
Date Issued
2016-11-01
Date Acceptance
2016-08-05
Citation
JOURNAL OF IMMUNOLOGY, 2016, 197 (9), pp.3628-3638
ISSN
0022-1767
Publisher
AMER ASSOC IMMUNOLOGISTS
Start Page
3628
End Page
3638
Journal / Book Title
JOURNAL OF IMMUNOLOGY
Volume
197
Issue
9
Copyright Statement
© 2016 The Authors This is an open-access article distributed under the terms of the CC-BY 3.0 Unported license (https://creativecommons.org/licenses/by/3.0/).
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000387965900022&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Immunology
NONINHERITED MATERNAL ANTIGENS
MURINE LEUKEMIA VIRUSES
FRIEND-VIRUS
ENDOGENOUS RETROVIRUSES
IMMUNE-RESPONSES
VIRAL-INFECTION
INDUCED TUMORS
LYMPHOCYTES-T
I/LNJ MICE
MECHANISMS
Publication Status
Published
Date Publish Online
2016-10-21