Intraoperative tissue identification by mass spectrometric technologies
File(s)
Published version
Author(s)
St John, ER
Rossi, M
Pruski, P
Darzi, A
Takats, Z
Type
Journal Article
Abstract
Mass spectrometric (MS) approaches developed for tissue identification in surgical environments are reviewed. MS Imaging (MSI) techniques enable the direct analysis of human tissue and can be used as an alternative means for margin assessment. While MSI-based approaches were demonstrated to improve the examiner-related variance of the data, the time demand and the cost of these analyses remained high. Furthermore, the necessity of MS expertise for the clinical deployment of these techniques has hindered large-scale clinical testing. The advent of ‘ambient’ MS methods contributed to the application of MSI techniques in this field, however alternative methods have been developed for the direct analysis of tissue samples without sample preparation. One group of methods employs surgical tissue manipulation for ionization while the other one uses minimally invasive probes for sampling prior to ionization. The methods are summarised and compared with regard to the information delivered, turnaround time and tissue identification performance.
Date Issued
2016-05-10
Date Acceptance
2016-05-10
Citation
TrAC Trends in Analytical Chemistry, 2016, 85 (Part A), pp.2-9
ISSN
0165-9936
Publisher
Elsevier B.V.
Start Page
2
End Page
9
Journal / Book Title
TrAC Trends in Analytical Chemistry
Volume
85
Issue
Part A
Copyright Statement
© 2016 The Authors. Published by Elsevier B.V. Open access article under CC-BY 4.0 (https://creativecommons.org/licenses/by/4.0/)
Subjects
Science & Technology
Physical Sciences
Chemistry, Analytical
Chemistry
DESI, mass spectrometric imaging
MALDI
Margin assessment
Mass spectrometry
REIMS
Metabolic fingerprint
Surgery
Intraoperative
Cancer
DESORPTION ELECTROSPRAY-IONIZATION
HUMAN BRAIN-TUMORS
SOLID-PHASE MICROEXTRACTION
BREAST-CONSERVING SURGERY
MOHS MICROGRAPHIC SURGERY
MARGIN ASSESSMENT
NANOELECTROSPRAY IONIZATION
MOLECULAR ASSESSMENT
RESECTION MARGINS
COMPLEX MATRICES
0301 Analytical Chemistry
0399 Other Chemical Sciences
Analytical Chemistry
Publication Status
Published