Evaluating the clinical and cost-effectiveness of permissive hypotension in critically ill patients aged 65 years or over with vasodilatory hypotension: Statistical and health economic analysis plan for the 65 trial in article.
File(s)
Author(s)
Type
Journal Article
Abstract
The 65 trial is a pragmatic, multicentre, parallel-group, open-label, randomised clinical trial of permissive hypotension (targeting a mean arterial pressure target of 60-65 mmHg during vasopressor therapy) versus usual care in critically ill patients aged 65 years or over with vasodilatory hypotension. The trial will recruit 2600 patients from 65 United Kingdom adult general critical care units. The primary outcome is all-cause mortality at 90 days. An economic evaluation is embedded. This paper describes the proposed statistical and health economic analysis for the 65 trial.
Date Issued
2020-08-01
Date Acceptance
2020-02-01
Citation
Journal of the Intensive Care Society, 2020, 21 (3), pp.230-231
ISSN
1751-1437
Publisher
SAGE Publications
Start Page
230
End Page
231
Journal / Book Title
Journal of the Intensive Care Society
Volume
21
Issue
3
Copyright Statement
©The Intensive Care Society 2019. The final, definitive version of this paper has been published in Journal of the Intensive Care Society by Sage Publications Ltd. All rights reserved. It is available at: https://journals.sagepub.com/doi/10.1177/1751143719860387
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/32782462
PII: 10.1177_1751143720938894
Subjects
Vasopressors
clinical trial
critical care
health economics
intensive care
mean arterial pressure
statistical analysis plan
Publication Status
Published
Coverage Spatial
England
Date Publish Online
2020-07-29