Development of a rodent high energy blast injury model for investigating conditions associated with traumatic amputations
File(s)2046-3758.103.bjr-2020-0367.r1.pdf (1 MB)
Published version
Author(s)
Kazezian, Zepur
Yu, Xiancheng
Ramette, Martin
Macdonald, Warren
Bull, Anthony
Type
Journal Article
Abstract
In recent conflicts, most injuries to the extremities are due to blast resulting in a large number of lower limb amputations. These lead to heterotopic ossification (HO), phantom limb pain (PLP), and functional deficit. The mechanism of blast loading produces a combined facture and amputation. Therefore, to study these conditions, in vivo models that replicate this combined effect are required. The aim of this study is to develop a preclinical model of blast-induced lower limb amputation.
Date Issued
2021-03-05
Date Acceptance
2020-12-14
Citation
Bone and Joint Research, 2021, 10 (3), pp.1-8
ISSN
2046-3758
Publisher
The British Editorial Society of Bone & Joint Surgery
Start Page
1
End Page
8
Journal / Book Title
Bone and Joint Research
Volume
10
Issue
3
Copyright Statement
© 2021 Author(s) et al. This is an open- access article distributed under the terms of the Creative Commons Attribution Non- Commercial No Derivatives (CC BY- NC- ND4.0) licence, which permits the copying and redistribution of the work only, and provided the original author and source are credited. See https://creativecommons.org/licenses/by-nc-nd/4.0/.
Sponsor
The Royal British Legion
Identifier
https://online.boneandjoint.org.uk/doi/full/10.1302/2046-3758.103.BJR-2020-0367.R1
Grant Number
BMPF_P60304
Subjects
Science & Technology
Life Sciences & Biomedicine
Cell & Tissue Engineering
Orthopedics
Cell Biology
Blast injuries
Cadaveric rodent model
Lower limb injury
Blast injuries
Cadaveric rodent model
Lower limb injury
1103 Clinical Sciences
1106 Human Movement and Sports Sciences
Publication Status
Published
Date Publish Online
2021-03-05