Identification of nonlinear state-space systems from heterogeneous datasets
File(s)17-0014_03_MS.pdf (369.52 KB)
Accepted version
Author(s)
Pan, W
Yuan, Y
Ljung, L
Goncalves, J
Stan, G
Type
Journal Article
Abstract
This paper proposes a new method to identify nonlinear state-space systems from heterogeneous datasets. The method is described in the context of identifying biochemical/gene networks (i.e., identifying both reaction dynamics and kinetic parameters) from experimental data. Simultaneous integration of various datasets has the potential to yield better performance for system identification. Data collected experimentally typically vary depending on the specific experimental setup and conditions. Typically, heterogeneous data are obtained experimentally through 1) replicate measurements from the same biological system or 2) application of different experimental conditions such as changes/perturbations in biological inductions, temperature, gene knock-out, gene over-expression, etc. We formulate here the identification problem using a Bayesian learning framework that makes use of “sparse group” priors to allow inference of the sparsest model that can explain the whole set of observed heterogeneous data. To enable scale up to large number of features, the resulting nonconvex optimization problem is relaxed to a reweighted Group Lasso problem using a convex–concave procedure. As an illustrative example of the effectiveness of our method, we use it to identify a genetic oscillator (generalized eight species repressilator). Through this example we show that our algorithm outperforms Group Lasso when the number of experiments is increased, even when each single time-series dataset is short. We additionally assess the robustness of our algorithm against noise by varying the intensity of process noise and measurement noise.
Date Issued
2018-06-01
Date Acceptance
2017-09-17
Citation
IEEE Transactions on Control of Network Systems, 2018, 5 (2), pp.737-747
ISSN
2325-5870
Publisher
Institute of Electrical and Electronics Engineers
Start Page
737
End Page
747
Journal / Book Title
IEEE Transactions on Control of Network Systems
Volume
5
Issue
2
Sponsor
Engineering & Physical Science Research Council (EPSRC)
Engineering & Physical Science Research Council (EPSRC)
Identifier
https://ieeexplore.ieee.org/document/8055630
Grant Number
EP/M002187/1
EP/P009352/1
Subjects
Science & Technology
Technology
Automation & Control Systems
Computer Science, Information Systems
Computer Science
Biological system modeling
system identification
SPARSE
INFERENCE
NETWORKS
MODELS
CONVEX
0102 Applied Mathematics
0805 Distributed Computing
0906 Electrical and Electronic Engineering
Publication Status
Published
Date Publish Online
2017-10-02