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  4. Does age matter? The impact of rodent age on study outcomes
 
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Does age matter? The impact of rodent age on study outcomes
File(s)
Lab Anim-2016-Jackson-0023677216653984.pdf (483.53 KB)
Published version
Author(s)
Jackson, SJ
Andrews, N
Ball, D
Bellantuono, I
Gray, J
more
Type
Journal Article
Abstract
Rodent models produce data which underpin biomedical research and non-clinical drug trials, but translation from rodents into successful clinical outcomes is often lacking. There is a growing body of evidence showing that improving experimental design is key to improving the predictive nature of rodent studies and reducing the number of animals used in research. Age, one important factor in experimental design, is often poorly reported and can be overlooked. The authors conducted a survey to assess the age used for a range of models, and the reasoning for age choice. From 297 respondents providing 611 responses, researchers reported using rodents most often in the 6-20 week age range regardless of the biology being studied. The age referred to as 'adult' by respondents varied between six and 20 weeks. Practical reasons for the choice of rodent age were frequently given, with increased cost associated with using older animals and maintenance of historical data comparability being two important limiting factors. These results highlight that choice of age is inconsistent across the research community and often not based on the development or cellular ageing of the system being studied. This could potentially result in decreased scientific validity and increased experimental variability. In some cases the use of older animals may be beneficial. Increased scientific rigour in the choice of the age of rodent may increase the translation of rodent models to humans.
Date Issued
2016-06-15
Date Acceptance
2016-06-01
Citation
Laboratory Animals, 2016, 51 (2), pp.160-169
URI
http://hdl.handle.net/10044/1/34580
DOI
https://www.dx.doi.org/10.1177/0023677216653984
ISSN
1758-1117
Publisher
SAGE Publications
Start Page
160
End Page
169
Journal / Book Title
Laboratory Animals
Volume
51
Issue
2
Copyright Statement
© The Author(s) 2016. This article is distributed under the terms of the Creative Commons Attribution 3.0 License (http://www.creativecommons.org/licenses/by/3.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
License URL
http://creativecommons.org/licenses/by/4.0/
Identifier
PII: 0023677216653984
Subjects
Science & Technology
Life Sciences & Biomedicine
Veterinary Sciences
Zoology
rodent
age
experimental design
development
senescence
IMMUNE-SYSTEM
C57BL/6J MICE
MECHANICAL-PROPERTIES
PLASMA ESTRADIOL
DRUG DEVELOPMENT
C57B1/6 MICE
MOUSE
HUMANS
BONE
RAT
Age Factors
Aging
Animals
Biomedical Research
Mice
Rats
Terminology as Topic
0608 Zoology
0707 Veterinary Sciences
Publication Status
Published
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