Allergy in severe asthma
File(s)
Author(s)
Type
Journal Article
Abstract
It is well recognized that atopic sensitization is an important risk factor for asthma, both in adults and in children. However, the role of allergy in severe asthma is still under debate. The term 'Severe Asthma' encompasses a highly heterogeneous group of patients who require treatment on steps 4-5 of GINA guidelines to prevent their asthma from becoming 'uncontrolled', or whose disease remains 'uncontrolled' despite this therapy. Epidemiological studies on emergency room visits and hospital admissions for asthma suggest the important role of allergy in asthma exacerbations. In addition, allergic asthma in childhood is often associated with severe asthma in adulthood. A strong association exists between asthma exacerbations and respiratory viral infections, and interaction between viruses and allergy further increases the risk of asthma exacerbations. Furthermore, fungal allergy has been shown to play an important role in severe asthma. Other contributing factors include smoking, pollution and work-related exposures. The 'Allergy and Asthma Severity' EAACI Task Force examined the current evidence and produced this position document on the role of allergy in severe asthma.
Date Issued
2016-10-24
Date Acceptance
2016-10-19
Citation
Allergy, 2016, 72 (2), pp.207-220
ISSN
0105-4538
Publisher
Wiley
Start Page
207
End Page
220
Journal / Book Title
Allergy
Volume
72
Issue
2
Copyright Statement
© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. This is the accepted version of the following article: Del Giacco SR, Bakirtas A, Bel E, Custovic A, Diamant Z, Hamelmann E, Heffler E, Kalayci Ö, Saglani S, Sergejeva S, Seys S, Simpson A, Bjermer L. Allergy in severe asthma. Allergy 2016; DOI: 10.1111/all.13072., which has been published in final form at https://dx.doi.org/10.1111/all.13072
Sponsor
Medical Research Council (MRC)
Identifier
http://www.ncbi.nlm.nih.gov/pubmed/27775836
Grant Number
MR/K002449/1
Subjects
aetiology
allergy
asthma
atopy
severity
Allergy
1107 Immunology
Publication Status
Published
Coverage Spatial
Denmark