Ion channel dysfunction and fibrosis in atrial fibrillation: two sides of the same coin
File(s)
Accepted version
Author(s)
Type
Journal Article
Abstract
Background
Atrial fibrillation (AF) is a common heart rhythm disorder that is associated with an increased risk of stroke and heart failure (HF). Initially, an association between AF and ion channel dysfunction was identified, classifying the pathology as a predominantly electrical disease. More recently it has been recognized that fibrosis and structural atrial remodeling play a driving role in the development of this arrhythmia also in these cases.
Purpose
Understanding the role of fibrosis in genetic determined AF could be important to better comprise the pathophysiology of this arrhythmia and to refine its management also in nongenetic forms. In this review we analyze genetic and epigenetic mechanisms responsible for AF and their link with atrial fibrosis, then we will consider analogies with the pathophysiological mechanism in nongenetic AF, and discuss consequent therapeutic options.
Atrial fibrillation (AF) is a common heart rhythm disorder that is associated with an increased risk of stroke and heart failure (HF). Initially, an association between AF and ion channel dysfunction was identified, classifying the pathology as a predominantly electrical disease. More recently it has been recognized that fibrosis and structural atrial remodeling play a driving role in the development of this arrhythmia also in these cases.
Purpose
Understanding the role of fibrosis in genetic determined AF could be important to better comprise the pathophysiology of this arrhythmia and to refine its management also in nongenetic forms. In this review we analyze genetic and epigenetic mechanisms responsible for AF and their link with atrial fibrosis, then we will consider analogies with the pathophysiological mechanism in nongenetic AF, and discuss consequent therapeutic options.
Date Issued
2024-03-01
Date Acceptance
2024-01-23
Citation
PACE - Pacing and Clinical Electrophysiology, 2024, 47 (3), pp.417-428
ISSN
0147-8389
Publisher
Wiley
Start Page
417
End Page
428
Journal / Book Title
PACE - Pacing and Clinical Electrophysiology
Volume
47
Issue
3
Copyright Statement
© 2024 Wiley Periodicals LLC. This is the author’s accepted manuscript made available under a CC-BY licence in accordance with Imperial’s Research Publications Open Access policy (www.imperial.ac.uk/oa-policy)
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/38375940
Subjects
ABLATION
atrial fibrillation
BRUGADA SYNDROME
CALCIUM LEAK
Cardiac & Cardiovascular Systems
Cardiovascular System & Cardiology
channel dysfunction
Engineering
Engineering, Biomedical
epigenetic
EXPRESSION
fibrosis
genetic
LATE NA CURRENT
Life Sciences & Biomedicine
MICRORNA-21
MOLECULAR-BASIS
MUTATIONS
PATHOPHYSIOLOGY
PREVENTION
Science & Technology
Technology
Publication Status
Published
Coverage Spatial
United States
Date Publish Online
2024-02-20