Induction of fibroblast senescence generates a non-fibrogenic myofibroblast phenotype that differentially impacts on cancer prognosis
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Published version
Supporting information
Author(s)
Type
Journal Article
Abstract
Cancer-associated fibroblasts (CAF) remain a poorly characterized, heterogeneous cell population. Here we characterized two previously described tumor-promoting CAF sub-types, smooth muscle actin (SMA)-positive myofibroblasts and senescent fibroblasts, identifying a novel link between the two.
Date Issued
2016-12-15
Date Acceptance
2016-11-15
Citation
Aging, 2016, 9 (1), pp.114-132
ISSN
1945-4589
Publisher
Impact Journals
Start Page
114
End Page
132
Journal / Book Title
Aging
Volume
9
Issue
1
Copyright Statement
© 2016 The Authors. Published under a Creative Commons Attribution License (CC-BY). Under the CC BY, authors retain ownership of the copyright for their article, but authors allow anyone to download, reuse, reprint, modify, distribute, and/or copy articles in Aging journal, so long as the original authors and source are cited.
Subjects
collagen
extracellular matrix
myofibroblasts
senescence
senescent fibroblasts
tumor microenvironment
Developmental Biology
Publication Status
Published