Functional networks of inhibitory neurons orchestrate synchrony in the hippocampus
File(s)
Author(s)
Type
Journal Article
Abstract
Inhibitory interneurons are pivotal components of cortical circuits. Beyond providing inhibition, they have been proposed to coordinate the firing of excitatory neurons within cell assemblies. While the roles of specific interneuron subtypes have been extensively studied, their influence on pyramidal cell synchrony in vivo remains elusive. Employing an all-optical approach in mice, we simultaneously recorded hippocampal interneurons and pyramidal cells and probed the network influence of individual interneurons using optogenetics. We demonstrate that CA1 interneurons form a functionally interconnected network that promotes synchrony through disinhibition during awake immobility, while preserving endogenous cell assemblies. Our network model underscores the importance of both cell assemblies and dense, unspecific interneuron connectivity in explaining our experimental findings, suggesting that interneurons may operate not only via division of labor but also through concerted activity.
Editor(s)
Csicsvari, Jozsef
Date Issued
2024-10-01
Date Acceptance
2024-09-06
Citation
PLoS Biology, 2024, 22 (10)
ISSN
1544-9173
Publisher
Public Library of Science (PLoS)
Journal / Book Title
PLoS Biology
Volume
22
Issue
10
Copyright Statement
© 2024 Bocchio et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/39401246
PII: PBIOLOGY-D-24-01464
Subjects
ASSEMBLIES
BASKET
Biochemistry & Molecular Biology
Biology
FAST-SPIKING CELLS
INTERNEURONS
Life Sciences & Biomedicine
Life Sciences & Biomedicine - Other Topics
OSCILLATIONS
PLACE CELLS
POPULATION
PYRAMIDAL CELLS
RIPPLE
Science & Technology
SELECTIVITY
Publication Status
Published
Coverage Spatial
United States
Article Number
e3002837
Date Publish Online
2024-10-14