A digital platform for the design of patient-centric supply chains
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Published version
Author(s)
Triantafyllou, Niki
Bernardi, Andrea
Lakelin, Matthew
Shah, Nilay
Papathanasiou, Maria
Type
Journal Article
Abstract
Chimeric Antigen Receptor (CAR) T cell therapies have received increasing attention, showing promising results in the treatment of acute lymphoblastic leukaemia and aggressive B cell lymphoma. Unlike typical cancer treatments, autologous CAR T cell therapies are patient-specific; this makes them a unique therapeutic to manufacture and distribute. In this work, we focus on the development of a computer modelling tool to assist the design and assessment of supply chain structures that can reliably and cost-efficiently deliver autologous CAR T cell therapies. We focus on four demand scales (200, 500, 1000 and 2000 patients annually) and we assess the tool’s capabilities with respect to the design of responsive supply chain candidate solutions while minimising cost.
Date Issued
2022-10-17
Date Acceptance
2022-09-26
Citation
Scientific Reports, 2022, 12
ISSN
2045-2322
Publisher
Nature Publishing Group
Journal / Book Title
Scientific Reports
Volume
12
Copyright Statement
© The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
License URL
Sponsor
Engineering and Physical Sciences Research Council
Grant Number
EP/P006485/1
Subjects
Antigens, CD19
Humans
Immunotherapy, Adoptive
Lymphoma, B-Cell
Patient-Centered Care
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Receptors, Antigen, T-Cell
Receptors, Chimeric Antigen
Humans
Lymphoma, B-Cell
Receptors, Antigen, T-Cell
Antigens, CD19
Immunotherapy, Adoptive
Patient-Centered Care
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Receptors, Chimeric Antigen
Publication Status
Published
Article Number
ARTN 17365