An approach to the core of lactonamycin
File(s)
Accepted version
Author(s)
Type
Journal Article
Abstract
A cascade reaction has been developed for the synthesis of lactonamycin. In this paper, we demonstrate that a transition-metal-free thermal ene–diyne cyclization can be used for the construction of the entire core of the antibiotic lactonamycin and anticancer agent lactonamycin Z.
Date Issued
2017-05-19
Date Acceptance
2017-03-27
Citation
Organic Letters, 2017, 19 (10), pp.2533-2535
ISSN
1523-7060
Publisher
American Chemical Society
Start Page
2533
End Page
2535
Journal / Book Title
Organic Letters
Volume
19
Issue
10
Copyright Statement
© 2017 American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, after peer review and technical editing by the publisher. To access the final edited and published work see https://dx.doi.org/10.1021/acs.orglett.7b00902
Identifier
https://pubs.acs.org/doi/10.1021/acs.orglett.7b00902
Subjects
Science & Technology
Physical Sciences
Chemistry, Organic
Chemistry
CDEF RING-SYSTEM
2+2+2 CYCLOADDITION STRATEGY
STREPTOMYCES-RISHIRIENSIS
DIELS-ALDER
MODEL
CONSTRUCTION
ROUTE
Publication Status
Published
Date Publish Online
2017-04-26