Disseminated CMV infection and HLH in a patient with well-controlled HIV and ulcerative colitis
File(s)
Accepted version
Author(s)
Cockbain, Beatrice Clare
Mora Peris, Borja
Abbara, Aula
So, Chun Wah
Cooke, Graham
Type
Journal Article
Abstract
We present a case of haemophagocytic lymphohistiocytosis (HLH) in the context of disseminated cytomegalovirus (CMV) viraemia in a 50-year-old man with well-controlled HIV infection and ulcerative colitis (UC), for which he was receiving azathioprine. Peak CMV viral load was 371 000 copies/ml with evidence of end-organ CMV in the lungs and colon. A bone marrow biopsy showed evidence of haemophagocytosis of platelets, neutrophils and erythrocytes. The azathioprine was stopped, and he received intravenous ganciclovir and corticosteroids with suppression of the CMV viral load and resolution of the HLH.
Date Issued
2019-02-11
Date Acceptance
2019-01-07
Citation
BMJ Case Reports, 2019, 12 (2)
ISSN
1757-790X
Publisher
BMJ Publishing Group
Journal / Book Title
BMJ Case Reports
Volume
12
Issue
2
Copyright Statement
© BMJ Publishing Group Limited 2019. No commercial re-use. See rights and permissions. Published by BMJ.
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/30755430
PII: 12/2/bcr-2018-227916
Subjects
HIV / AIDS
immunology
infectious diseases
inflammatory bowel disease
pathology
Publication Status
Published
Coverage Spatial
England
Date Publish Online
2019-02-11