Mechanisms underpinning the efficacy of faecal microbiota transplantation in treating gastrointestinal disease
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
Faecal Microbiota transplantation is currently a recommended therapy for recurrent/refractory Clostridioides difficile infection. The success of FMT for CDI has led to interest in its therapeutic potential in many other disorders. The mechanisms that underpin the efficacy of FMT are not fully understood. Importantly, FMT remains a crucial treatment in managing CDI and hence understanding the mechanisms that underpin its success will be critical to improve its clinical efficacy, safety and usability. Furthermore, a deeper understanding may allow us to expose FMT’s full potential as a therapeutic tool for other disease states. This review will explore the current understanding of the mechanisms underlying the efficacy of FMT across a variety of diseases.
Date Issued
2020-09-03
Date Acceptance
2020-07-13
Citation
Therapeutic Advances in Gastroenterology, 2020, 13, pp.1-14
ISSN
1756-2848
Publisher
SAGE Publications
Start Page
1
End Page
14
Journal / Book Title
Therapeutic Advances in Gastroenterology
Volume
13
Copyright Statement
© The Author(s), 2020.
Article reuse guidelines:
sagepub.com/journalspermissions. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
Article reuse guidelines:
sagepub.com/journalspermissions. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
License URL
Sponsor
Imperial College Healthcare NHS Trust- BRC Funding
Identifier
https://journals.sagepub.com/doi/10.1177/1756284820946904
Grant Number
RDA02
Subjects
1103 Clinical Sciences
1115 Pharmacology and Pharmaceutical Sciences
Publication Status
Accepted
Date Publish Online
2020-09-03