Numerical model for magnetic fluid hyperthermia in a realistic breast phantom: calorimetric calibration and treatment planning
File(s)
Published version
Author(s)
Miaskowski, A
Subramanian, Mahendran
Type
Journal Article
Abstract
Thispaper aims to apply a proposed, based on calorimetric measurements, a reliable numerical model for magnetic fluid hyperthermia (MFH) treatment planning of breast cancer. Furthermore, we perform a comparative analysis of magnetic nanoparticles (MNPs) and tumour tissue interactions by means of the magnetic-field-dependent Néel and Brownian relaxation times. The analysis was based on an anatomically correct breast model (developed in-house) and a modified linear response theory, which was applied to investigate the heat dissipation from the magnetic nanoparticles dispersed in the breast tumour. The calculations of the single-domain magnetic power losses were conducted for a case where the magnetic field value and the applied frequency wereknown,but also for the different concentrations of the MNPs in the tumour. Two scenarios were considered: The MNPs mobilisedand immobilisedin the tumour. In parallel, the eddy currents effect, together with the related temperature distributions, were considered in order to analyse safety issues. By changing the MNP concentration in the tumour, the corresponding temperature distributions were calculated. The eddy current effect, together with the related temperature distribution, were considered in order to analysesafety issues. Varying the MNP concentration in the tumour, the corresponding temperature distribution wascalculated. Moreover, the cumulative equivalent minutes at 43°C were analysed. In the anatomically correct breast phantoms, the tissue location can lead to “hot spots” due to the eddy current effect and subsequently to the high gradients of the temperature. That is why the analysis of safety issues related to the overheating side effect should be taken into consideration during the treatment planning of magnetic fluid hyperthermia. The phenomenon of heat dissipation from MNPs is very sophisticated 31and depends on their concentration, the distribution and the relaxation mechanism in the tumour, together with magnetic field strength and frequency. Furthermore, we inferred that the phenomenon of heat dissipation from MNPs equally depends on MNP-tissue interactions, and it can lead to 30% differences in the power assessment. Nevertheless, the aforementioned factors should be considered in parallel using anatomical,volume-dependent models to enhance the efficiency ofin vivo treatment.
Date Issued
2019-09-19
Date Acceptance
2019-09-17
Citation
International Journal of Molecular Sciences, 2019, 20 (18)
ISSN
1422-0067
Publisher
MDPI AG
Journal / Book Title
International Journal of Molecular Sciences
Volume
20
Issue
18
Copyright Statement
© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access
article distributed under the terms and conditions of the Creative Commons Attribution
(CC BY) license (http://creativecommons.org/licenses/by/4.0/).
article distributed under the terms and conditions of the Creative Commons Attribution
(CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Subjects
breast cancer
magnetic fluid hyperthermia
numerical modelling
treatment planning
0399 Other Chemical Sciences
0604 Genetics
0699 Other Biological Sciences
Chemical Physics
Publication Status
Published
Article Number
ARTN 4644