Due to the confinement effect, the blast load from a confined space explosion tends to cause more severe damage to structures. When subjected to this type of confined explosion, thermoplastic fibre–metal laminate (TFML) panels would experience repeated shock waves and relatively longer durations of quasi-static pressure. A better understanding of the dynamic response and damage mechanism of TFMLs under confined blast loading can greatly benefit the design of composite structures with improved blast resistance. In the present work, TFMLs with seven different configurations were designed and fabricated. Confined-blast experiments with various masses of trinitrotoluene (TNT) were performed on these TFMLs. The experimental results, including deflection time histories and X-ray computed tomography (CT) images, have been applied to the development of a method for predicting the dynamic response of laminates under confined blast loads. The findings of this work will assist in the rapid assessment of the deformation of fibre–metal laminates and assist in the pre-design of laminate structures in confined explosions.