Importance of Endogenous Fibrinolysis in Platelet Thrombus Formation
File(s)
Published version
Author(s)
Gue, Ying X
Gorog, Diana A
Type
Journal Article
Abstract
The processes of thrombosis and coagulation are finely regulated by endogenous fibrinolysis
maintaining healthy equilibrium. When the balance is altered in favour of platelet activation and/or
coagulation, or if endogenous fibrinolysis becomes less efficient, pathological thrombosis can occur.
Arterial thrombosis remains a major cause of morbidity and mortality in the world despite advances
in medical therapies. The role endogenous fibrinolysis in the pathogenesis of arterial thrombosis has
gained increasing attention in recent years as it presents novel ways to prevent and treat existing
diseases. In this review article, we discuss the role of endogenous fibrinolysis in platelet thrombus
formation, methods of measurement of fibrinolytic activity, its role in predicting cardiovascular
diseases and clinical outcomes and future directions.
maintaining healthy equilibrium. When the balance is altered in favour of platelet activation and/or
coagulation, or if endogenous fibrinolysis becomes less efficient, pathological thrombosis can occur.
Arterial thrombosis remains a major cause of morbidity and mortality in the world despite advances
in medical therapies. The role endogenous fibrinolysis in the pathogenesis of arterial thrombosis has
gained increasing attention in recent years as it presents novel ways to prevent and treat existing
diseases. In this review article, we discuss the role of endogenous fibrinolysis in platelet thrombus
formation, methods of measurement of fibrinolytic activity, its role in predicting cardiovascular
diseases and clinical outcomes and future directions.
Date Issued
2017-08-25
Date Acceptance
2017-08-21
Citation
International Journal of Molecular Sciences, 2017, 18 (9)
ISSN
1422-0067
Publisher
MDPI AG
Journal / Book Title
International Journal of Molecular Sciences
Volume
18
Issue
9
Copyright Statement
© 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access
article distributed under the terms and conditions of the Creative Commons Attribution
(CC BY) license (http://creativecommons.org/licenses/by/4.0/).
article distributed under the terms and conditions of the Creative Commons Attribution
(CC BY) license (http://creativecommons.org/licenses/by/4.0/).
License URL
Subjects
Science & Technology
Life Sciences & Biomedicine
Physical Sciences
Biochemistry & Molecular Biology
Chemistry, Multidisciplinary
Chemistry
endogenous
spontaneous
thrombolysis
fibrinolysis
thrombosis
platelets
cardiovascular
ACUTE MYOCARDIAL-INFARCTION
CORONARY-ARTERY-DISEASE
SPONTANEOUS THROMBOLYTIC ACTIVITY
PLASMINOGEN-ACTIVATOR INHIBITOR-1
REDUCED CLOT PERMEABILITY
C-REACTIVE PROTEIN
GRACE RISK SCORE
HEART-DISEASE
CARDIOVASCULAR DEATH
PRIMARY ANGIOPLASTY
Publication Status
Published
Article Number
1850