Food protein-induced enterocolitis (FPIES) is a non
-IgE, cell- mediated food allergic
disorder that can be severe and lead to shock.
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In spite of the potential seriousness of
reactions, awareness of FPIES is low, high-quality
studies providing insight into the
pathophysiology, diagnosis, and management are lack
ing, and clinical outcomes are
poorly established. Unmet needs in the field includ
e identification of the non-invasive
biomarkers, clear understanding of the disease mech
anisms, data regarding
prevalence, and having uniform approaches to diagno
sis and management. This
document is the first international consensus based
on the available evidence and aims
to assist practitioners in their care for the patie
nts with FPIES.