Intestinal permeability and bacterial translocation in patients with liver disease, focusing on alcoholic aetiology: methods of assessment and therapeutic intervention
Author(s)
Skinner, Charlotte
Thompson, Alex J
Thursz, Mark R
Marchesi, Julian R
Vergis, Nikhil
Type
Journal Article
Abstract
Increased bacterial translocation (BT) across the gut barrier due to greater intestinal permeability (IP) is seen across a range of conditions, including alcohol-related liver disease (ArLD). The phenomenon of BT may contribute to both the pathogenesis and the development of complications in ArLD. There are a number of methods available to assess IP and in this review we look at their various advantages and limitations. The knowledge around BT and IP in ArLD is also reviewed, as well as the therapeutic strategies currently in use and in development.
Date Issued
2020-10-16
Date Acceptance
2020-06-25
Citation
Therapeutic Advances in Gastroenterology, 2020, 13, pp.1-16
ISSN
1756-2848
Publisher
SAGE Publications
Start Page
1
End Page
16
Journal / Book Title
Therapeutic Advances in Gastroenterology
Volume
13
Copyright Statement
© The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
License URL
Sponsor
Wellcome Trust ISSF
Medical Research Council (MRC)
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000581485400001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Grant Number
294834/Z/16/Z ISSF ICL
MR/R014019/1
Subjects
Science & Technology
Life Sciences & Biomedicine
Gastroenterology & Hepatology
alcohol-related liver disease
bacterial translocation
cirrhosis
gut barrier
intestinal permeability
LIPOPOLYSACCHARIDE-BINDING PROTEIN
MESENTERIC LYMPH-NODES
TIGHT JUNCTIONS
CIRRHOTIC-PATIENTS
DOUBLE-BLIND
NONALCOHOLIC CIRRHOSIS
GASTROINTESTINAL-TRACT
SYSTEMIC INFLAMMATION
INDIGENOUS BACTERIA
HUMAN ZONULIN
Publication Status
Published
Article Number
ARTN 1756284820942616
Date Publish Online
2020-10-16