Chemokine subversion by human herpesviruses
File(s)
Accepted version
Author(s)
Pontejo, Sergio
Murphy, Philip
Pease, JE
Type
Journal Article
Abstract
Viruses use diverse molecular mechanisms to exploit and evade the immune response. Herpesviruses, in particular, encode functional chemokine and chemokine receptor homologs pirated from the host, as well as secreted chemokine-binding proteins with unique structures. Multiple functions have been described for herpesvirus chemokine components, including attraction of target cells, blockade of leukocyte migration, and modulation of gene expression and cell entry by the virus. Here we review current concepts about how human herpesvirus chemokines, chemokine receptors, and chemokine-binding proteins may be used to shape a proviral state in the host.
Date Issued
2018-01-01
Date Acceptance
2018-07-11
Citation
Journal of Innate Immunity, 10 (5-6), pp.465-478
ISSN
1662-811X
Publisher
Karger Publishers
Start Page
465
End Page
478
Journal / Book Title
Journal of Innate Immunity
Volume
10
Issue
5-6
Copyright Statement
© 2018 S. Karger AG, Basel. This is the peer-reviewed but unedited manuscript version of the article. The final, published version is available at https://dx.doi.org/10.1159/000492161
Identifier
https://www.karger.com/Article/FullText/492161
Subjects
Science & Technology
Life Sciences & Biomedicine
Immunology
Chemokines
Chemokine receptors
Viral infection
PROTEIN-COUPLED RECEPTOR
SARCOMA-ASSOCIATED HERPESVIRUS
EPSTEIN-BARR-VIRUS
OPEN READING FRAME
US27 GENE-PRODUCT
HUMAN CYTOMEGALOVIRUS
KAPOSIS-SARCOMA
VMIP-II
VIRAL CHEMOKINE
ENDOTHELIAL-CELLS
Chemokine receptors
Chemokines
Viral infection
11 Medical and Health Sciences
Publication Status
Published
Date Publish Online
2018-08-30