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One-step room temperature fabrication of freeze-cast 58S bioactive glass / polyvinyl alcohol composite scaffolds for bone tissue engineering
File(s)
Author(s)
dos Santos, Diogo MM
de Oliveira, Gustavo L
Soares, Daniel CF
Maia, Matheus V
Heyraud, Agathe
Type
Journal Article
Abstract
This study investigates freeze-cast composite scaffolds for bone tissue engineering using sol-gel-derived 58S bioactive glass (BG) and polyvinyl alcohol (PVA). Designed to mimic bone's mechanical properties, scaffolds with varying BG/PVA ratios were produced. The scaffolds were characterized for morphology, pore structure, chemical composition, bioactivity, and cytotoxicity. Increasing PVA content from 5 % to 20 % raised compressive strength from (2.0 ± 0.3) MPa to (16.7 ± 3.0) MPa and toughness from (2.0 ± 0.3) MPa to (194.6 ± 21.3) MPa. However, higher BG content increased brittleness. The 95/05 BG/PVA scaffold demonstrated rapid formation of carbonated hydroxyapatite (HAp) within 24 h of immersion in simulated body fluid, achieving a Ca/P ratio of 1.87, close to that of stoichiometric HAp. In vitro assays confirmed high cell viability (over 90 %) and active proliferation, indicating biocompatibility. This study highlights the potential of these scaffolds for bone regeneration, offering promising insights for biomaterials in regenerative medicine. It is important to note that these materials have been prepared using a simple approach that does not require heat treatment. This method offers significant advantages in terms of energy efficiency and cost savings.
Date Issued
2025-07-01
Date Acceptance
2025-02-20
Citation
Ceramics International, 2025, 51 (16), pp.21393-21401
URI
URL
DOI
ISSN
0272-8842
Publisher
Elsevier BV
Start Page
21393
End Page
21401
Journal / Book Title
Ceramics International
Volume
51
Issue
16
Copyright Statement
Copyright © 2025 Elsevier Ltd and Techna Group S.r.l. This is the author’s accepted manuscript made available under a CC-BY licence in accordance with Imperial’s Research Publications Open Access policy (www.imperial.ac.uk/oa-policy)
License URL
Publication Status
Published
Article Number
Part A
Date Publish Online
2025-02-24