Too Much, Too Little or Just Enough: A Goldilocks Effect for IL-13 and Skin Barrier Regulation?
File(s)Goldilocks commentary Final Nov 29th.docx (123.34 KB)
Accepted version
Author(s)
Strid, J
McLean, WH
Irvine, AD
Type
Journal Article
Abstract
The mechanistic relationship between IL-4/IL-13 and skin barrier function has been of interest since the filaggrin discovery and the subsequent in vitro demonstration that IL-4 and IL-13 downregulate filaggrin expression in cultured keratinocytes. Hönzke and colleagues explore these interactions further. The effects of IL-4/ll-13 may be context dependent, with differing roles in homeostasis and in disease.
Date Issued
2016-03-01
Date Acceptance
2016-02-19
Citation
Journal of Investigative Dermatology, 2016, 136 (3), pp.561-564
ISSN
1523-1747
Publisher
Elsevier
Start Page
561
End Page
564
Journal / Book Title
Journal of Investigative Dermatology
Volume
136
Issue
3
Copyright Statement
© 2016, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor
Wellcome Trust
Identifier
PII: S0022-202X(15)00321-8
Grant Number
100999/Z/13/Z
Subjects
Dermatology & Venereal Diseases
1103 Clinical Sciences
1112 Oncology And Carcinogenesis
Publication Status
Published