Uniform surface modification of 3D Bioglass®-based scaffolds with mesoporous silica particles (MCM-41) for enhancing drug delivery capability
Author(s)
Type
Journal Article
Abstract
The design and characterization of a new family of multifunctional scaffolds based on bioactive glass (BG) of 45S5 composition for bone tissue engineering and drug delivery applications are presented. These BG-based scaffolds are developed via a replication method of polyurethane packaging foam. In order to increase the therapeutic functionality, the scaffolds were coated with mesoporous silica particles (MCM-41), which act as an in situ drug delivery system. These sub-micron spheres are characterized by large surface area and pore volume with a narrow pore diameter distribution. The solution used for the synthesis of the silica mesoporous particles was designed to obtain a high-ordered mesoporous structure and spherical shape – both are key factors for achieving the desired controlled drug release. The MCM-41 particles were synthesized directly inside the BG-based scaffolds, and the drug-release capability of this combined system was evaluated. Moreover, the effect of MCM-41 particle coating on the bioactivity of the BG-based scaffolds was assessed. The results indicate that it is possible to obtain a multifunctional scaffold system characterized by high and interconnected porosity, high bioactivity, and sustained drug delivery capability.
Date Issued
2015-11-06
Date Acceptance
2015-10-15
Citation
Frontiers in Bioengineering and Biotechnology, 2015, 3
ISSN
2296-4185
Publisher
Frontiers Media
Journal / Book Title
Frontiers in Bioengineering and Biotechnology
Volume
3
Copyright Statement
© 2015 Boccardi, Philippart, Juhasz-Bortuzzo, Beltrán, Novajra, Vitale-Brovarone, Spiecker and Boccaccini. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
License URL
Subjects
MCM-41
bioactive glass
drug release
ibuprofen
ordered mesoporosity
scaffolds
silica
Publication Status
Published
Article Number
177