The bacillary and macrophage response to hypoxia in tuberculosis and the consequences for T cell antigen recognition
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Accepted version
Published version
Author(s)
Type
Journal Article
Abstract
M. tuberculosis is a facultative anaerobe and its characteristic pathological hallmark, the granuloma, exhibits hypoxia in humans and in most experimental models. Thus the host and bacillary adaptation to hypoxia is of central importance in understanding pathogenesis and thereby to derive new drug treatments and vaccines.
Date Issued
2016-10-22
Date Acceptance
2016-10-06
Citation
Microbes and Infection, 2016, 19 (3), pp.177-192
ISSN
1286-4579
Publisher
Elsevier
Start Page
177
End Page
192
Journal / Book Title
Microbes and Infection
Volume
19
Issue
3
Copyright Statement
Creative Commons Attribution 4.0 International (CC BY 4.0)
License URL
Sponsor
Wellcome Trust
Grant Number
104803/Z/14/ZR
Subjects
Science & Technology
Life Sciences & Biomedicine
Immunology
Infectious Diseases
Microbiology
Tuberculosis
Hypoxia
T cells
Antigens
Macrophage
Lipid droplets
HOST-PATHOGEN INTERACTIONS
ENDOTHELIAL GROWTH-FACTOR
TUMOR-NECROSIS-FACTOR
MYCOBACTERIUM-TUBERCULOSIS
LATENT TUBERCULOSIS
GENE-EXPRESSION
PULMONARY TUBERCULOSIS
IN-VITRO
LIPID-METABOLISM
DOSR REGULON
Animals
Disease Models, Animal
Humans
Macrophages
Mycobacterium tuberculosis
T-Lymphocytes
0605 Microbiology
1107 Immunology
1108 Medical Microbiology
Publication Status
Published