IFITM3 and susceptibility to respiratory viral infections in the community

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Author(s)

Mills, Tara C

Rautanen, Anna

Elliott, Katherine S

Parks, Tom

Naranbhai, Vivek

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Type

Journal Article

Abstract

Interferon-inducible transmembrane proteins 1, 2, and 3 (IFITM 1,2, and 3) are viral restriction factors that mediate cellular resistance to several viruses. We have genotyped a possible splice-site altering single-nucleotide polymorphism (rs12252) in the IFITM3 gene in 34 patients with H1N1 influenza and severe pneumonia, and >5000 individuals comprising patients with community-acquired mild lower respiratory tract infection and matched controls of Caucasian ancestry. We found evidence of an association between rs12252 rare allele homozygotes and susceptibility to mild influenza (in patients attending primary care) but could not confirm a previously reported association between this single-nucleotide polymorphism and susceptibility to severe H1N1 infection.

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Date Issued

2014-04-01

Date Acceptance

2013-08-05

Citation

Journal of Infectious Diseases, 2014, 209 (7), pp.1028-1031

URI

http://hdl.handle.net/10044/1/99689

URL

https://academic.oup.com/jid/article/209/7/1028/876868

DOI

https://www.dx.doi.org/10.1093/infdis/jit468

ISSN

0022-1899

Publisher

Oxford University Press

Start Page

1028

End Page

1031

Journal / Book Title

Journal of Infectious Diseases

Volume

209

Issue

7

Copyright Statement

© The Author 2013. Published by Oxford University Press on behalf of the Infectious Diseases Society of America.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/ licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

License URL

http://creativecommons.org/ licenses/by/3.0/

Identifier

https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000333087900009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202

Subjects

Science & Technology

Life Sciences & Biomedicine

Immunology

Infectious Diseases

Microbiology

genetics

H1N1

Influenza

LRTI

infectious disease

IFITM3

association study

Virus

WEST NILE VIRUS

DENGUE VIRUS

INFLUENZA

ASSOCIATION

PROTEINS

Publication Status

Published

Date Publish Online

2013-08-30