Association of height growth in puberty with lung function: a longitudinal study
File(s)
Author(s)
Type
Journal Article
Abstract
RATIONALE: Puberty may influence lung function, but the precise role of pubertal height growth in lung development is unclear. OBJECTIVES: To examine associations of timing of puberty and peak velocity of pubertal height growth with lung function in adolescence and early-adulthood. METHODS: Longitudinal analyses of repeat height measurements from age 5-20 years for a British birth cohort with 4,772 males and 4,849 females were conducted to characterise height growth trajectories, and derive pubertal age and peak height velocity using the validated SuperImposition by Translation and Rotation (SITAR) model. Association of these estimates with pre-bronchodilator and post-bronchodilator spirometry measures: FEV1; FVC; FEV1/FVC; FEF25-75 at age 15 and 24 years were investigated using multivariable regression models adjusted for lung function at age 8 years, height and age at time of outcome measurements, and potential confounders. MEASUREMENTS AND MAIN RESULTS: Later pubertal age and greater peak velocity were associated with higher FEV1 and FVC at 24 years in both sexes. A 1-year advanced pubertal age was associated with a 263 ml higher FVC (95% confidence interval: 167, 360) for males (n=567), 100 ml (50, 150) for females (n=990). A 1-cm/year increase in peak velocity was associated with 145 ml (56, 234) and 50 ml (2, 99) increase in FVC for males and females respectively. No associations were found with FEV1/FVC. CONCLUSIONS: Later onset and greater peak velocity of height growth in puberty are associated with increased FEV1 and FVC in young adults but there was no evidence of dysanapsis of pubertal lung growth.
Date Issued
2018-12-15
Date Acceptance
2018-07-06
Citation
American Journal of Respiratory and Critical Care Medicine, 2018, 198 (12), pp.1539-1548
ISSN
1073-449X
Publisher
American Thoracic Society
Start Page
1539
End Page
1548
Journal / Book Title
American Journal of Respiratory and Critical Care Medicine
Volume
198
Issue
12
Copyright Statement
© 2018 American Thoracic Society.
Sponsor
Commission of the European Communities
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/29995435
Grant Number
633212
Subjects
ALSPAC
Maximal lung function
Pubertal age
SITAR
Velocity of pubertal height growth
Publication Status
Published online
Coverage Spatial
United States
Date Publish Online
2018-07-11