The quality and efficiency of high-speed machining are restricted by the matching performance of the motorized spindle-tool holder. In high speed cutting process, the mating surface is subjected to alternating torque, repeated clamping wear and centrifugal force, which results in serious degradation of mating performance. Therefore, for the purpose of the optimum maintenance time, periodic evaluation and prediction of remaining useful life (RUL) should be carried out. Firstly, the mapping model between the current of the motorized spindle and matching performance was extracted, and the degradation characteristics of spindle-tool holder were emphatically analyzed. After the original current is de-noised by an adaptive threshold function, the extent of degradation was identified by the amplitudes of wavelet packet entropy. A hybrid prognostics combining Relevance Vector Machine (RVM) i.e. AI-model with power regression i.e. statistical model was proposed to predict the RUL. Finally, the proposed scheme was verified based on a motorized spindle reliability test platform. The experimental results show that the current signal processing method based on wavelet packet and entropy can reflect the change of the degradation characteristics sensitively. Compared with other two similar models, the hybrid model proposed can accurately predict the RUL. This model is suitable for complex and high reliability equipment when Condition Monitoring (CM) data is scarcer.