The sequence grammar and interactions controlling the aging of protein biomolecular condensates
File(s)
Published version
Author(s)
Thrush, Rebecca
Aprile, Francesco
Type
Journal Article
Abstract
Biomolecular condensates play key roles in the cell by organizing and regulating important biochemical processes, including transcriptional regulation, RNA metabolism, ribosome biogenesis, and stress responses. While these assemblies are typically dynamic, they can undergo time-dependent aging into solid assemblies, which has been linked to pathologies including neurodegenerative disease and cancer. In this review, we focus on the mechanisms that drive condensate aging. In particular, we discuss how features of protein sequence, such as amino acid composition, interaction motifs, and post-translational modifications, influence condensate aging. We further highlight how interactions with RNA and lipid membranes modulate condensate behavior by altering interaction networks and interfacial properties.
Date Issued
2026-08-01
Date Acceptance
2026-06-02
Citation
Current Opinion in Structural Biology, 2026, 99
ISSN
0959-440X
Publisher
Elsevier
Journal / Book Title
Current Opinion in Structural Biology
Volume
99
Copyright Statement
© 2026 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
License URL
Identifier
10.1016/j.sbi.2026.103309
Publication Status
Published
Article Number
103309
Date Publish Online
2026-07-15