Tenofovir disoproxil fumarate fails to prevent HIV acquisition or the establishment of a viral reservoir: two case reports
Author(s)
Type
Journal Article
Abstract
The use of antiretrovirals as pre-exposure prophylaxis (PrEP) is highly efficacious in HIV prevention. The World Health Organization recently recommended Truvada(®) (Gilead Sciences, Inc.) or tenofovir disoproxil fumarate (TDF) for high-risk individuals, with limited data for single-agent TDF PrEP in men who have sex with men (MSM). We report two cases of TDF PrEP failure in MSM who had received long-term TDF for hepatitis B infection and had therapeutic levels of drug immediately after HIV acquisition. Rapid antiretroviral intensification at diagnosis of acute HIV infection failed to limit immune dysfunction or prevent the establishment of a viral reservoir.
Date Issued
2016-01-09
Date Acceptance
2016-01-09
Citation
Infectious Diseases and Therapy, 2016, 5 (1), pp.65-71
ISSN
2193-8229
Publisher
Springer Verlag and Adis
Start Page
65
End Page
71
Journal / Book Title
Infectious Diseases and Therapy
Volume
5
Issue
1
Copyright Statement
This article is distributed
under the terms of the Creative Commons
Attribution-NonCommercial 4.0 International
License (http://creativecommons.org/licenses/
by-nc/4.0/), which permits any noncommercial
use, distribution, and reproduction
in any medium, provided you give appropriate
credit to the original author(s) and the source,
provide a link to the Creative Commons license,
and indicate if changes were made
under the terms of the Creative Commons
Attribution-NonCommercial 4.0 International
License (http://creativecommons.org/licenses/
by-nc/4.0/), which permits any noncommercial
use, distribution, and reproduction
in any medium, provided you give appropriate
credit to the original author(s) and the source,
provide a link to the Creative Commons license,
and indicate if changes were made
Sponsor
Imperial College Healthcare NHS Trust- BRC Funding
University Of Oxford
Identifier
PII: 10.1007/s40121-015-0102-x
Grant Number
RDA02 79560
n/a
Subjects
HIV
Pre-exposure prophylaxis
Tenofovir
Viral reservoir
Publication Status
Published