The role of endothelial cells in pulmonary hypertension: old concepts and new science
File(s)
Published version
Author(s)
Haensel, Maike
Wojciak-Stothard, Beata
Type
Journal Article
Abstract
Endothelial dysfunction plays a key role in the initiation and progression of pulmonary hypertension (PH), a fatal and currently incurable disease associated with increased pulmonary vascular resistance and leading to right heart failure. Recent data from genomic, transcriptomic and metabolomic studies and emergence of novel organ-on-chip technologies have provided new insights into the role of endothelium in the pathogenesis of this disease. In this review, we characterise key features of endothelial dysfunction in PH, highlighting the diversity of endothelial cell types and differences in their responses to vascular insults. We also present the current understanding of the effects of genetic mutations on endothelial function and comment on new ways of disease modelling using organ-on-chip technologies.
Date Issued
2023-08
Date Acceptance
2023-03-01
Citation
Current Opinion in Physiology, 2023, 34
ISSN
2468-8673
Publisher
Elsevier
Journal / Book Title
Current Opinion in Physiology
Volume
34
Copyright Statement
Crown Copyright © 2023 Published by Elsevier B.V. All
rights reserved. This is an open access article under the CC BY
license (http://creativecommons.org/licenses/by/4.0/).
rights reserved. This is an open access article under the CC BY
license (http://creativecommons.org/licenses/by/4.0/).
License URL
Identifier
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:001053842700001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
Subjects
ANGIOGENESIS
APOPTOSIS
ARTERIAL-HYPERTENSION
CAVEOLIN-1
CHANNELS
DEFICIENCY
Life Sciences & Biomedicine
MECHANISMS
Physiology
PLEXIFORM LESIONS
Science & Technology
TISSUE KALLIKREIN
VASCULAR-PERMEABILITY
Publication Status
Published
Article Number
100667
Date Publish Online
2023-03-30