Epidermal deletion of HIF-2 alpha stimulates wound closure
File(s)
Author(s)
Type
Journal Article
Abstract
Wound closure requires a complex series of micro-environmentally influenced events. A key aspect of wound closure is the migration of keratinocytes across the open wound. It has been found previously that the response to hypoxia via the HIF-1α transcription factor is a key feature of wound closure. The need for hypoxic response is likely due to interrupted wound vasculature, as well as infection, and in this work we investigated the need for a highly related hypoxic response transcription factor, HIF-2α. This factor was deleted tissue specifically in mice, and the resulting mice were found to have an accelerated rate of wound closure. This is correlated with a reduced bacterial load and inflammatory response in these mice. This indicates that manipulating or reducing the HIF-2α response in keratinocytes could be a useful means to accelerate wound healing and tissue repair.
Date Issued
2014-03-01
Date Acceptance
2013-08-28
Citation
Journal of Investigative Dermatology, 2014, 134 (3), pp.801-808
ISSN
0022-202X
Publisher
Elsevier
Start Page
801
End Page
808
Journal / Book Title
Journal of Investigative Dermatology
Volume
134
Issue
3
Copyright Statement
© 2015 Elsevier Ltd. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000331669800030&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Dermatology
ENDOTHELIAL PROGENITOR CELLS
KERATINOCYTE MIGRATION
EXPRESSION
HIF-1-ALPHA
HIF-1
NEOVASCULARIZATION
CONTRIBUTES
RECRUITMENT
INDUCTION
OXYGEN
Publication Status
Published
Date Publish Online
2015-12-08