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Disparate regulation of IMD signaling drives sex differences in infection pathology in Drosophila melanogaster
File(s)
e2026554118.full.pdf (822.49 KB)
Published version
OA Location
Author(s)
Vincent, Crystal M
Dionne, Marc S
Type
Journal Article
Abstract
Male and female animals exhibit differences in infection outcomes. One possible source of sexually dimorphic immunity is the sex-specific costs of immune activity or pathology, but little is known about the independent effects of immune- versus microbe-induced pathology and whether these may differ for the sexes. Here, by measuring metabolic and physiological outputs in Drosophila melanogaster with wild-type and mutant immune responses, we test whether the sexes are differentially impacted by these various sources of pathology and identify a critical regulator of this difference. We find that the sexes exhibit differential immune activity but similar bacteria-derived metabolic pathology. We show that female-specific immune-inducible expression of PGRP-LB, a negative regulator of the immune deficiency (IMD) pathway, enables females to reduce immune activity in response to reductions in bacterial numbers. In the absence of PGRP-LB, females are more resistant to infection, confirming the functional importance of this regulation and suggesting that female-biased immune restriction comes at a cost.
Date Issued
2021-08-10
Date Acceptance
2021-08-01
Citation
Proceedings of the National Academy of Sciences, 2021, 118 (32), pp.1-10
URI
URL
DOI
ISSN
0027-8424
Publisher
Proceedings of the National Academy of Sciences
Start Page
1
End Page
10
Journal / Book Title
Proceedings of the National Academy of Sciences
Volume
118
Issue
32
Copyright Statement
© 2021 the Author(s). Published by PNAS. This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY).
License URL
Sponsor
Wellcome Trust
Medical Research Council (MRC)
Medical Research Council (MRC)
Identifier
https://www.pnas.org/content/118/32/e2026554118
Grant Number
207467/Z/17/Z
MR/R00997X/1
MR/R00997X/1
Publication Status
Published
Date Publish Online
2021-08-02