Responses to auxin signals: an operating principle for dynamical sensitivity yet high resilience
File(s)
Published version
Author(s)
Grigolon, S
Bravi, B
Martin, OC
Type
Journal Article
Abstract
Plants depend on the signalling of the phytohormone auxin for their development and for responding to environmental perturbations. The associated biomolecular signalling network involves a negative feedback on Aux/IAA proteins which mediate the influence of auxin (the signal) on the auxin response factor (ARF) transcription factors (the drivers of the response). To probe the role of this feedback, we consider alternative in silico signalling networks implementing different operating principles. By a comparative analysis, we find that the presence of a negative feedback allows the system to have a far larger sensitivity in its dynamical response to auxin and that this sensitivity does not prevent the system from being highly resilient. Given this insight, we build a new biomolecular signalling model for quantitatively describing such Aux/IAA and ARF responses.
Date Issued
2018-01
Date Acceptance
2017-12-08
Citation
Royal Society Open Science, 2018, 5 (1), pp.1-15
ISSN
2054-5703
Publisher
The Royal Society
Start Page
1
End Page
15
Journal / Book Title
Royal Society Open Science
Volume
5
Issue
1
Copyright Statement
© 2018 The Authors. Published by the Royal Society under the terms of the Creative Commons
Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted
use, provided the original author and source are credited.
Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted
use, provided the original author and source are credited.
License URL
Identifier
https://royalsocietypublishing.org/doi/10.1098/rsos.172098
Publication Status
Published
Date Publish Online
2018-01-24