Survival and quality of life benefit after endoscopic management of malignant central airway obstruction
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
BACKGROUND: Although interventional management of malignant central airway obstruction (mCAO) is well established, its impact on survival and quality of life (QoL) has not been extensively studied. AIM: We prospectively assessed survival, QoL and dyspnea (using validated EORTC questionnaire) in patients with mCAO 1 day before interventional bronchoscopy, 1 week after and every following month, in comparison to patients who declined this approach. Material/Patients/Methods: 36 patients underwent extensive interventional bronchoscopic management as indicated, whereas 12 declined. All patients received full chemotherapy and radiotherapy as indicated. Patients of the 2 groups were matched for age, comorbidities, type of malignancy and level of obstruction. Follow up time was 8.0±8.7 (range 1-38) months. RESULTS: Mean survival for intervention and control group was 10±9 and 4±3 months respectively (p=0.04). QoL improved significantly in intervention group patients up to the 6(th) month (p<0.05) not deteriorating for those surviving up to 12 months. Dyspnea decreased in patients of the intervention group 1 month post procedure remaining reduced for survivors over the 12th month. Patients of the control group had worse QoL and dyspnea in all time points. CONCLUSIONS: Interventional management of patients with mCAO, may achieve prolonged survival with sustained significant improvement of QoL and dyspnea.
Date Issued
2016-04-25
Date Acceptance
2016-03-21
Citation
Journal of Cancer, 2016, 7 (7), pp.794-802
ISSN
1837-9664
Publisher
Ivyspring International Publisher
Start Page
794
End Page
802
Journal / Book Title
Journal of Cancer
Volume
7
Issue
7
Copyright Statement
© Ivyspring International Publisher 2016. Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited. See http://ivyspring.com/terms for terms and conditions.
Identifier
PII: jcav07p0794
Subjects
intervention
lung cancer
quality of life.
Publication Status
Published
Date Publish Online
2016-04-25