Langerin-expressing dendritic cells in pulmonary immune-related diseases
File(s)
Author(s)
Type
Journal Article
Abstract
Dendritic cells (DCs) are "frontline" immune cells dedicated to antigen presentation. They serve as an important bridge connecting innate and adaptive immunity, and express various receptors for antigen capture. DCs are divided into various subclasses according to their differential expression of cell surface receptors and different subclasses of DCs exhibit specific immunological characteristics. Exploring the common features of each sub-category has became the focus of many studies. There are certain amounts of DCs expressing langerin in airways and peripheral lungs while the precise mechanism by which langerin+ DCs drive pulmonary disease is unclear. Langerin-expressing DCs can be further subdivided into numerous subtypes based on the co-expressed receptors, but here, we identify commonalities across these subtypes that point to the major role of langerin. Better understanding is required to clarify key disease pathways and determine potential new therapeutic approaches.
Date Issued
2022-09-07
Date Acceptance
2022-08-12
Citation
Frontiers of Medicine, 2022, 9
ISSN
1673-7342
Publisher
Springer
Journal / Book Title
Frontiers of Medicine
Volume
9
Copyright Statement
© 2022 Xuan, Li, Wu, Adcock, Zeng and Yao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/36160158
Subjects
dendritic cells
immunity
langerin
pathogenesis
pulmonary immune-related disease
Publication Status
Published
Coverage Spatial
Switzerland
Article Number
ARTN 909057