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Impact of pH and chloride content on the biodegradation of magnesium alloys for medical implants: an in vitro and phase-field study
File(s)
Author(s)
Kovacevic, Sasa
Ali, Wahaaj
Mandal, Tushar Kanti
Martínez-Pañeda, Emilio
LLorca, Javier
Type
Journal Article
Abstract
The individual contributions of pH and chloride concentration to the corrosion kinetics of bioabsorbable magnesium (Mg) alloys remain unresolved despite their significant roles as driving factors in Mg corrosion. This study demonstrates and quantifies hitherto unknown separate effects of pH and chloride content on the corrosion of Mg alloys pertinent to biomedical implant applications. The experimental setup designed for this purpose enables the quantification of the dependence of corrosion on pH and chloride concentration. The in vitro tests conclusively demonstrate that variations in chloride concentration, relevant to biomedical applications, have a negligible effect on corrosion kinetics. The findings identify pH as a critical factor in the corrosion of bioabsorbable Mg alloys. A variationally consistent phase-field model is developed for assessing the degradation of Mg alloys in biological fluids. The model accurately predicts the corrosion performance of Mg alloys observed during the experiments, including their dependence on pH and chloride concentration. The capability of the framework to account for mechano-chemical effects during corrosion is demonstrated in practical orthopedic applications considering bioabsorbable Mg alloy implants for bone fracture fixation and porous scaffolds for bone tissue engineering. The strategy has the potential to assess the in vitro and in vivo service life of bioabsorbable Mg-based biomedical devices.
Date Issued
2025-05-15
Date Acceptance
2025-03-17
Citation
Acta Biomaterialia, 2025, 198, pp.546-565
URI
URL
DOI
ISSN
1742-7061
Publisher
Elsevier
Start Page
546
End Page
565
Journal / Book Title
Acta Biomaterialia
Volume
198
Copyright Statement
© 2025 The Authors. Published by Elsevier Inc. on behalf of Acta Materialia Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
License URL
Identifier
10.1016/j.actbio.2025.03.034
Publication Status
Published
Date Publish Online
2025-04-06