Transcription factors regulated by cAMP in smooth muscle of the myometrium at human parturition.
File(s)
Published version
OA Location
Author(s)
Li, Jonathan KH
Lai, Pei F
Tribe, Rachel M
Johnson, Mark R
Type
Journal Article
Abstract
Cyclic adenosine monophosphate (cAMP) contributes to maintenance of a quiescent (relaxed) state in the myometrium (i.e. uterine smooth muscle) during pregnancy, which most commonly has been attributed to activation of protein kinase A (PKA). PKA-mediated phosphorylation of cytosolic contractile apparatus components in myometrial smooth muscle cells (mSMCs) are known to promote relaxation. Additionally, PKA also regulates nuclear transcription factor (TF) activity to control expression of genes important to the labour process; these are mostly involved in actin-myosin interactions, cell-to-cell connectivity and inflammation, all of which influence mSMC transition from a quiescent to a contractile (pro-labour) phenotype. This review focuses on the evidence that cAMP modulates the activity of TFs linked to pro-labour gene expression, predominantly cAMP response element (CRE) binding TFs, nuclear factor κB (NF-κB), activator protein 1 (AP-1) family and progesterone receptors (PRs). This review also considers the more recently described exchange protein directly activated by cAMP (EPAC) that may oppose the pro-quiescent effects of PKA, as well as explores findings from other cell types that have the potential to be of novel relevance to cAMP action on TF function in the myometrium.
Date Issued
2021-04-16
Date Acceptance
2021-03-23
Citation
Biochemical Society Transactions, 2021, 49 (2), pp.997-1011
ISSN
0300-5127
Publisher
Portland Press
Start Page
997
End Page
1011
Journal / Book Title
Biochemical Society Transactions
Volume
49
Issue
2
Copyright Statement
© 2021 The Author(s). This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY).
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/33860781
PII: 228374
Subjects
bZIP transcription factors
cAMP
muscle contraction
pregnancy
signal transducers and activators of transcription
uterus
Publication Status
Published
Coverage Spatial
England
Date Publish Online
2021-04-16