Effectiveness of seasonal influenza vaccine in preventing laboratory-confirmed influenza in primary care in the United Kingdom: 2015/16 mid-season results
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Published version
Author(s)
Type
Journal Article
Abstract
In 2015/16, the influenza season in the United Kingdom
was dominated by influenza A(H1N1)pdm09 circulation.
Virus characterisation indicated the emergence of
genetic clusters, with the majority antigenically similar
to the current influenza A(H1N1)pdm09 vaccine strain.
Mid-season vaccine effectiveness (VE) estimates show
an adjusted VE of 41.5% (95% confidence interval (CI):
3.0–64.7) against influenza-confirmed primary care
consultations and of 49.1% (95% CI: 9.3–71.5) against
influenza A(H1N1)pdm09. These estimates show levels
of protection similar to the 2010/11 season, when this
strain was first used in the seasonal vaccine.
was dominated by influenza A(H1N1)pdm09 circulation.
Virus characterisation indicated the emergence of
genetic clusters, with the majority antigenically similar
to the current influenza A(H1N1)pdm09 vaccine strain.
Mid-season vaccine effectiveness (VE) estimates show
an adjusted VE of 41.5% (95% confidence interval (CI):
3.0–64.7) against influenza-confirmed primary care
consultations and of 49.1% (95% CI: 9.3–71.5) against
influenza A(H1N1)pdm09. These estimates show levels
of protection similar to the 2010/11 season, when this
strain was first used in the seasonal vaccine.
Date Issued
2016-03-31
Date Acceptance
2016-03-30
Citation
Eurosurveillance, 2016, 21 (13), pp.31-38
ISSN
1560-7917
Publisher
European Centre for Disease Prevention and Control
Start Page
31
End Page
38
Journal / Book Title
Eurosurveillance
Volume
21
Issue
13
Copyright Statement
This is an open-access article distributed under the terms of
the Creative Commons Attribution (CC BY 4.0) Licence. You
may share and adapt the material, but must give appropriate
credit to the source, provide a link to the licence, and indicate
if changes were made.
This article is copyright of the authors, 2016.
the Creative Commons Attribution (CC BY 4.0) Licence. You
may share and adapt the material, but must give appropriate
credit to the source, provide a link to the licence, and indicate
if changes were made.
This article is copyright of the authors, 2016.
License URL
Subjects
Science & Technology
Life Sciences & Biomedicine
Infectious Diseases
VIRUSES
PCR
Publication Status
Published
Article Number
30179