A continuous flow process for the defluorosilylation of HFC-23 and HFO-1234yf
File(s)
Author(s)
Patrick, Sarah L
Bull, James A
Miller, Philip W
Crimmin, Mark R
Type
Journal Article
Abstract
A continuous flow process has been developed for the defluorosilylation of trifluoromethane (HFC-23) and 2,3,3,3-tetrafluoropropene (HFO-1234yf) through reaction with lithium silanide reagents under inert conditions. Design of experiment optimization improved process conditions, including productivity, yields, reduction of solvent use, and gas destruction. The small chain fluorinated organosilane products R3SiCF2H and R3SiCH2C(F)═CF2 were competent nucleophiles in the fluoride-catalyzed difluoromethylation of aldehydes, and trifluoroallylation of aldehydes, ketones, and imines.
Date Issued
2024-10-11
Date Acceptance
2024-09-27
Citation
Organic Letters, 2024, 26 (40), pp.8605-8609
ISSN
1523-7060
Publisher
American Chemical Society
Start Page
8605
End Page
8609
Journal / Book Title
Organic Letters
Volume
26
Issue
40
Copyright Statement
© 2024 The Authors. Published by American Chemical Society. This publication is licensed under CC-BY 4.0 .
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/39352945
Subjects
CARBONYL-COMPOUNDS
Chemistry
Chemistry, Organic
CUCF3
DIFLUOROMETHYLATION
EFFICIENT
FLUORINE
FLUOROFORM
HFC-125
KETONES
Physical Sciences
Science & Technology
TRIFLUOROMETHYLATION
Publication Status
Published
Coverage Spatial
United States
Date Publish Online
2024-10-01