Synthesis and hetero-diels–alder reactions of enantiomerically pure dihydro-1H-azepines
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Published version
Author(s)
Craig, Donald
Spreadbury, Samuel RJ
White, Andrew JP
Type
Journal Article
Abstract
Thermolysis of enantiomerically pure 3-substituted 7,7-dihalo-2-azabicyclo[4.1.0]heptanes in the presence of K2CO3 gives in good yields 2-alkyl-6-halo-1-tosyl-2,3-dihydro-1H-azepines. These undergo highly stereoselective [4+2] cycloaddition reactions with heterodienophiles and arylation/alkenylation under Suzuki conditions.
Date Issued
2020-07-14
Date Acceptance
2020-07-10
Citation
Chemical Communications, 2020, 56 (68), pp.9803-9806
ISSN
1359-7345
Publisher
Royal Society of Chemistry
Start Page
9803
End Page
9806
Journal / Book Title
Chemical Communications
Volume
56
Issue
68
Copyright Statement
© The Royal Society of Chemistry 2020 This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.
License URL
Identifier
https://pubs.rsc.org/en/content/articlelanding/2020/CC/D0CC04413J#!divAbstract
Subjects
Organic Chemistry
03 Chemical Sciences
Publication Status
Published
Date Publish Online
2020-07-14