Synthesis of isoindolinones by Pd-catalyzed coupling between N-methoxybenzamide and styrene derivatives
File(s)Changkun(JOC)revisedsubmission [clean copy].pdf (854.11 KB)
Accepted version
Author(s)
Xia, C
White, AJ
Hii, KK
Type
Journal Article
Abstract
An atom-economical protocol for a tandem process involving Fujiwara-Moritani-aza-Wacker reactions has been developed for the Pd-catalyzed coupling between N-methoxy benzamide with styrene derivatives. The generality of the methodology was demonstrated by the synthesis of a library of twenty-five 3-benzylidene isoindolinones in moderate to good yields. A further twenty-two 3-benzyl derivatives were obtained by telescoping the process with a catalytic hydrogenation reaction.
Date Issued
2016-08-05
Date Acceptance
2016-07-14
Citation
Journal of Organic Chemistry, 2016, 81 (17), pp.7931-7938
ISSN
1520-6904
Publisher
American Chemical Society
Start Page
7931
End Page
7938
Journal / Book Title
Journal of Organic Chemistry
Volume
81
Issue
17
Copyright Statement
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Organic Chemistry, © 2016 American Chemical Society, after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/acs.joc.6b01696.
Subjects
Organic Chemistry
0304 Medicinal And Biomolecular Chemistry
0305 Organic Chemistry
0302 Inorganic Chemistry
Publication Status
Published