Symptomatic, biochemical and radiographic recovery in patients with Covid-19
File(s)e000908.full.pdf (330.82 KB)
Published version
Author(s)
Type
Journal Article
Abstract
Background: The symptoms, radiography, biochemistry and healthcare utilisation of patients with COVID-19 following discharge from hospital have not been well described.
Methods: Retrospective analysis of 401 adult patients attending a clinic following an index hospital admission or emergency department attendance with COVID-19. Regression models were used to assess the association between characteristics and persistent abnormal chest radiographs or breathlessness.
Results: 75.1% of patients were symptomatic at a median of 53 days post discharge and 72 days after symptom onset and chest radiographs were abnormal in 47.4%. Symptoms and radiographic abnormalities were similar in PCR-positive and PCR-negative patients. Severity of COVID-19 was significantly associated with persistent radiographic abnormalities and breathlessness. 18.5% of patients had unscheduled healthcare visits in the 30 days post discharge.
Conclusions: Patients with COVID-19 experience persistent symptoms and abnormal blood biomarkers with a gradual resolution of radiological abnormalities over time. These findings can inform patients and clinicians about expected recovery times and plan services for follow-up of patients with COVID-19.
Methods: Retrospective analysis of 401 adult patients attending a clinic following an index hospital admission or emergency department attendance with COVID-19. Regression models were used to assess the association between characteristics and persistent abnormal chest radiographs or breathlessness.
Results: 75.1% of patients were symptomatic at a median of 53 days post discharge and 72 days after symptom onset and chest radiographs were abnormal in 47.4%. Symptoms and radiographic abnormalities were similar in PCR-positive and PCR-negative patients. Severity of COVID-19 was significantly associated with persistent radiographic abnormalities and breathlessness. 18.5% of patients had unscheduled healthcare visits in the 30 days post discharge.
Conclusions: Patients with COVID-19 experience persistent symptoms and abnormal blood biomarkers with a gradual resolution of radiological abnormalities over time. These findings can inform patients and clinicians about expected recovery times and plan services for follow-up of patients with COVID-19.
Date Issued
2021-04-07
Date Acceptance
2021-03-24
Citation
BMJ Open Respiratory Research, 2021, 8 (1)
ISSN
2052-4439
Publisher
BMJ Publishing Group
Journal / Book Title
BMJ Open Respiratory Research
Volume
8
Issue
1
Copyright Statement
© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
License URL
Sponsor
Imperial College Healthcare NHS Trust- BRC Funding
Grant Number
RDA02
Subjects
Science & Technology
Life Sciences & Biomedicine
Respiratory System
COVID-19
BURDEN
RESOLUTION
ILLNESS
TIME
COVID-19
Aftercare
Biomarkers
COVID-19
Female
Humans
Male
Middle Aged
Patient Acceptance of Health Care
Patient Discharge
Radiography, Thoracic
Recovery of Function
Retrospective Studies
SARS-CoV-2
Severity of Illness Index
Symptom Assessment
Time Factors
United Kingdom
Humans
Radiography, Thoracic
Aftercare
Patient Discharge
Severity of Illness Index
Retrospective Studies
Recovery of Function
Time Factors
Middle Aged
Patient Acceptance of Health Care
Female
Male
Symptom Assessment
Biomarkers
United Kingdom
COVID-19
SARS-CoV-2
Publication Status
Published
Article Number
ARTN e000908
Date Publish Online
2021-04-07