Transcription regulation and membrane stress management in enterobacterial pathogens
File(s)
Accepted version
Author(s)
Type
Journal Article
Abstract
Transcription regulation in a temporal and conditional manner underpins the lifecycle of enterobacterial pathogens. Upon exposure to a wide array of environmental cues, these pathogens modulate their gene expression via the RNA polymerase and associated sigma factors. Different sigma factors, either involved in general 'house-keeping' or specific responses, guide the RNA polymerase to their cognate promoter DNAs. The major alternative sigma54 factor when activated helps pathogens manage stresses and proliferate in their ecological niches. In this chapter, we review the function and regulation of the sigma54-dependent Phage shock protein (Psp) system-a major stress response when Gram-negative pathogens encounter damages to their inner membranes. We discuss the recent development on mechanisms of gene regulation, signal transduction and stress mitigation in light of different biophysical and biochemical approaches.
Date Issued
2016-05-19
Date Acceptance
2016-05-01
Citation
Advances in Experimental Medicine and Biology, 2016, 915, pp.207-230
ISSN
0065-2598
Publisher
Kluwer
Start Page
207
End Page
230
Journal / Book Title
Advances in Experimental Medicine and Biology
Volume
915
Copyright Statement
© 2016 Springer International Publishing Switzerland. The final publication is available at Springer via http://dx.doi.org/10.1007/978-3-319-32189-9_13
Subjects
Membrane stress
Psp
RNA polymerase
Sigma factors
Transcription
Publication Status
Published
Date Publish Online
2016-05-19