Transient and partial nuclear lamina disruption promotes chromosome movement in early meiotic prophase
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
Meiotic chromosome movement is important for the pairwise alignment of homologous chromosomes, which is required for correct chromosome segregation. Movement is driven by cytoplasmic forces, transmitted to chromosome ends by nuclear membrane-spanning proteins. In animal cells, lamins form a prominent scaffold at the nuclear periphery, yet the role lamins play in meiotic chromosome movement is unclear. We show that chromosome movement correlates with reduced lamin association with the nuclear rim, which requires lamin phosphorylation at sites analogous to those that open lamina network crosslinks in mitosis. Failure to remodel the lamina results in delayed meiotic entry, altered chromatin organization, unpaired or interlocked chromosomes, and slowed chromosome movement. The remodeling kinases are delivered to lamins via chromosome ends coupled to the nuclear envelope, potentially enabling crosstalk between the lamina and chromosomal events. Thus, opening the lamina network plays a role in modulating contacts between chromosomes and the nuclear periphery during meiosis.
Date Issued
2018-04-23
Date Acceptance
2018-03-23
Citation
Developmental Cell, 2018, 45 (2), pp.212-225
ISSN
1534-5807
Publisher
Elsevier
Start Page
212
End Page
225
Journal / Book Title
Developmental Cell
Volume
45
Issue
2
Copyright Statement
© 2018 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
License URL
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000430689800008&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Cell Biology
Developmental Biology
C. ELEGANS MEIOSIS
CAENORHABDITIS-ELEGANS
PORE COMPLEXES
CDC2 KINASE
ENVELOPE
MITOSIS
SYNAPSIS
PHOSPHORYLATION
PROGRESSION
CELLS
Publication Status
Published
Date Publish Online
2018-04-23