Recent advances in the synthesis of α-amino ketones
File(s)
Published version
Author(s)
Allen, Lewis
Raclea, Robert-Cristian
Natho, Philipp
Parsons, Philip
Type
Journal Article
Abstract
Due to the importance of the amino ketone motif in synthetic and medicinal chemistry, the number of protocols developed in recent years has considerably increased. This review serves to collate and critically evaluate novel methodologies published since 2011 towards this high value synthon. The chapters are divided by the requisite functionality in the starting material, and an emphasis is placed on discussing functional group compatibility and resultant product substitution patterns. Throughout, applications to medicinal targets are highlighted and mechanistic details are presented, and we further provide a short outlook for future development and emerging potential within this area.
Date Issued
2021-01-21
Date Acceptance
2020-12-02
Citation
Organic and Biomolecular Chemistry, 2021, 19 (3), pp.498-513
ISSN
1477-0520
Publisher
Royal Society of Chemistry
Start Page
498
End Page
513
Journal / Book Title
Organic and Biomolecular Chemistry
Volume
19
Issue
3
Copyright Statement
© The Royal Society of Chemistry 2021. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (https://creativecommons.org/licenses/by/3.0/)
License URL
Subjects
Organic Chemistry
0304 Medicinal and Biomolecular Chemistry
0305 Organic Chemistry
Publication Status
Published
Date Publish Online
2020-12-08