Bayesian credible subgroup identification for treatment effectiveness in time-to-event data.
Author(s)
Type
Journal Article
Abstract
Due to differential treatment responses of patients to pharmacotherapy, drug development and practice in medicine are concerned with personalized medicine, which includes identifying subgroups of population that exhibit differential treatment effect. For time-to-event data, available methods only focus on detecting and testing treatment-by-covariate interactions and may not consider multiplicity. In this work, we introduce the Bayesian credible subgroups approach for time-to-event endpoints. It provides two bounding subgroups for the true benefiting subgroup: one which is likely to be contained by the benefiting subgroup and one which is likely to contain the benefiting subgroup. A personalized treatment effect is estimated by two common measures of survival time: the hazard ratio and restricted mean survival time. We apply the method to identify benefiting subgroups in a case study of prostate carcinoma patients and a simulated large clinical dataset.
Date Issued
2020-02-26
Date Acceptance
2020-02-04
Citation
PLoS One, 2020, 15 (2), pp.1-19
ISSN
1932-6203
Publisher
Public Library of Science (PLoS)
Start Page
1
End Page
19
Journal / Book Title
PLoS One
Volume
15
Issue
2
Copyright Statement
© 2020 Ngo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/32101562
PII: PONE-D-19-19585
Subjects
General Science & Technology
Publication Status
Published online
Coverage Spatial
United States
Date Publish Online
2020-02-26