The link between neuroinflammation and the neurovascular unit in synucleinopathies.
File(s)
Author(s)
Wang, Qing
Zheng, Jialing
Pettersson, Sven
Reynolds, Richard
Tan, Eng-King
Type
Journal Article
Abstract
The neurovascular unit (NVU) is composed of vascular cells, glial cells, and neurons. As a fundamental functional module in the central nervous system, the NVU maintains homeostasis in the microenvironment and the integrity of the blood-brain barrier. Disruption of the NVU and interactions among its components are involved in the pathophysiology of synucleinopathies, which are characterized by the pathological accumulation of α-synuclein. Neuroinflammation contributes to the pathophysiology of synucleinopathies, including Parkinson's disease, multiple system atrophy, and dementia with Lewy bodies. This review aims to summarize the neuroinflammatory response of glial cells and vascular cells in the NVU. We also review neuroinflammation in the context of the cross-talk between glial cells and vascular cells, between glial cells and pericytes, and between microglia and astroglia. Last, we discuss how α-synuclein affects neuroinflammation and how neuroinflammation influences the aggregation and spread of α-synuclein and analyze different properties of α-synuclein in synucleinopathies.
Date Issued
2023-02-15
Date Acceptance
2023-01-19
Citation
Science Advances, 2023, 9 (7), pp.1-16
ISSN
2375-2548
Publisher
American Association for the Advancement of Science
Start Page
1
End Page
16
Journal / Book Title
Science Advances
Volume
9
Issue
7
Copyright Statement
Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/36791205
Subjects
alpha-Synuclein
Humans
Neuroinflammatory Diseases
Neurons
Parkinson Disease
Synucleinopathies
Publication Status
Published
Coverage Spatial
United States
Date Publish Online
2023-02-15